PrimePCR™ Probe Assay: USP18, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: USP18, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: USP18, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0054966
Assay Design:   exonic
Chromosome Location:   22:18659595-18659716question
Amplicon Length:   92
Splice Variants Targeted:   ENST00000215794

Gene Information

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon suggesting a function of this protein in downregulating interferon responses independent of its isopeptidase activity towards ISG15. [provided by RefSeq Sep 2011]

Gene Symbol:   USP18
Gene Name:   ubiquitin specific peptidase 18
Aliases:   ISG43, UBP43
RefSeq:   NC_000022.10 NT_011519.10
Ensembl:   ENSG00000184979
Entrez:   11274
Chromosome Mapping:   22q11.21

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