PrimePCR™ Probe Assay: TYK2, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: TYK2, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: TYK2, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0029076
Assay Design:   Intron-spanning
Chromosome Location:   19:10473270-10475432question
Amplicon Length:   177
Splice Variants Targeted:   ENST00000524462 ENST00000525621 ENST00000529370 ENST00000525220 ENST00000264818 ENST00000543792

Gene Information

This gene encodes a member of the tyrosine kinase and more specifically the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq Jul 2008]

Gene Symbol:   TYK2
Gene Name:   tyrosine kinase 2
Aliases:   JTK1
RefSeq:   NC_000019.9 NG_007872.1 NT_011295.11
Ensembl:   ENSG00000105397
Entrez:   7297
Chromosome Mapping:   19p13.2

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