PrimePCR™ lncRNA® Probe Assay:PPARD, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression.

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   Same primer pair as used in SYBR assay qhsaLED0134536

List Price:    $247.00
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PrimePCR™ IncRNA PreAmp for Probe Assay: PPARD, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ IncRNA Template for Probe Assay: PPARD, Human
Reaction:     4 billion copies/200 µl
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   lncRNA Expression
Unique Assay ID:   qhsaLEP0211776
Assay Design:   exonic
Chromosome Location:   chr6:35426981-35427204question
Amplicon Length:   194
Refseq Transcripts Amplified:   NM_001171818,NM_006238,NM_001171820,NM_001171819,XM_017010974,XM_005249193,XM_017010971,XM_011514707,XM_011514709,XM_017010972,XM_006715120,XM_011514710,XM_017010973,XM_006715123,XM_017010975
Splice Variants Targeted:   ENST00000418635 ENST00000311565 ENST00000360694 ENST00000448077
LNCipedia Splice Variants Targeted:   lnc-FANCE-1:1

Gene Information

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes and may be involved in the development of several chronic diseases including diabetes obesity atherosclerosis and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC) a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum lipid metabolism and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq Jan 2010]

Gene Symbol:   PPARD
Gene Name:   peroxisome proliferator-activated receptor delta
Aliases:   FAAR, MGC3931, NR1C2, NUC1, NUCI, NUCII, PPARB
RefSeq:   NC_000006.11 NT_007592.15 NG_012345.1
Ensembl:   ENSG00000112033
LNCipedia:   lnc-FANCE-1
Entrez:   5467
Chromosome Mapping:   6p21.2
Gene Strand:   Not Available

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