PrimePCR™ Probe Assay: CLDN18, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0030690
Assay Design:   Intron-spanning
Chromosome Location:   3:137743542-137749850question
Amplicon Length:   145
Splice Variants Targeted:   ENST00000343735 ENST00000183605 ENST00000536138

Gene Information

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq Jun 2010]

Gene Symbol:   CLDN18
Gene Name:   claudin 18
Aliases:   DKFZp564B2062, SFTA5, SFTPJ
RefSeq:   NC_000003.11 NT_005612.16
Ensembl:   ENSG00000066405
Entrez:   51208
Chromosome Mapping:   3q22.3

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