PrimePCR™ Probe Assay: Cldn3, Mouse

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qMmuCEP0031959
Assay Design:   Exonic
Chromosome Location:   5:134986726-134986884question
Amplicon Length:   129
Splice Variants Targeted:   ENSMUST00000094245

Gene Information

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a low-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein is highly overexpressed in uterine carcinosarcoma. This protein is also predominantly present in brain endothelial cells where it plays a specific role in the establishment and maintenance of blood brain barrier tight junction morphology. [provided by RefSeq Aug 2012]

Gene Symbol:   Cldn3
Gene Name:   Claudin 3
Aliases:   AI182374, Cpetr2, mRVP1
RefSeq:   NC_000071.6 NT_039314.8
Ensembl:   ENSMUSG00000070473
Entrez:   12739
Chromosome Mapping:   5 G2|5 75.0 cM

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