Gene:  MDM2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53 as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53 diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle apoptosis and tumorigenesis through interactions with other proteins including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: MDM2, Rhesus Monkey
Uncharacterized protein

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qMccCED0017474
List Price:    $140.00
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PrimePCR™ Probe Assay: MDM2, Rhesus Monkey
Uncharacterized protein

Assay Type: Probe
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qMccCEP0037658
List Price:    $270.00
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