PrimePCR™ lncRNA® Probe Assay:PPM1A, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression.

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   Same primer pair as used in SYBR assay qhsaLED0103931

List Price:    $260.00
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PrimePCR™ IncRNA PreAmp for Probe Assay: PPM1A, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ IncRNA Template for Probe Assay: PPM1A, Human
Reaction:     4 billion copies/200 µl
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   lncRNA Expression
Unique Assay ID:   qhsaLEP0181171
Assay Design:   exonic
Chromosome Location:   chr14:60282713-60282851question
Amplicon Length:   109
Splice Variants Targeted:   ENST00000395076 ENST00000325642 ENST00000531143 ENST00000325658 ENST00000525399 ENST00000528241 ENST00000531937
LNCipedia Splice Variants Targeted:   lnc-C14orf135-2:1

Gene Information

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates and negatively regulates the activities of MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53 which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq Jul 2008]

Gene Symbol:   PPM1A
Gene Name:   protein phosphatase, Mg2+/Mn2+ dependent, 1A
Aliases:   FLJ42306, MGC9201, PP2C-ALPHA, PP2CA, PP2Calpha
RefSeq:   NC_000014.8 NT_026437.12
Ensembl:   ENSG00000100614
LNCipedia:   lnc-C14orf135-2
Entrez:   5494
Chromosome Mapping:   14q23.1
Gene Strand:   Not Available

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