PrimePCR™ lncRNA® Probe Assay:ABL1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression.

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   Same primer pair as used in SYBR assay qhsaLED0104639

List Price:    $247.00
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PrimePCR™ IncRNA PreAmp for Probe Assay: ABL1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ IncRNA Template for Probe Assay: ABL1, Human
Reaction:     4 billion copies/200 µl
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   lncRNA Expression
Unique Assay ID:   qhsaLEP0181879
Assay Design:   exonic
Chromosome Location:   chr9:130714141-130714250question
Amplicon Length:   80
Refseq Transcripts Amplified:   NM_007313
Splice Variants Targeted:   ENST00000393293 ENST00000372348
LNCipedia Splice Variants Targeted:   lnc-EXOSC2-3:1

Gene Information

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation cell division cell adhesion and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq Jul 2008]

Gene Symbol:   ABL1
Gene Name:   c-abl oncogene 1, non-receptor tyrosine kinase
Aliases:   ABL, JTK7, bcr/abl, c-ABL, p150, v-abl
RefSeq:   NC_000009.11 NT_035014.4 NG_012034.1
Ensembl:   ENSG00000097007
LNCipedia:   lnc-EXOSC2-3
Entrez:   25
Chromosome Mapping:   9q34.1
Gene Strand:   Not Available

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