PrimePCR™ Probe Assay: IL10RA, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0027835
Assay Design:   Intron-spanning
Chromosome Location:   11:117864044-117864762question
Amplicon Length:   101
Splice Variants Targeted:   ENST00000227752 ENST00000541785 ENST00000536858 ENST00000545409

Gene Information

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10 and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants one protein-coding and the other not protein-coding have been found for this gene. [provided by RefSeq Jan 2009]

Gene Symbol:   IL10RA
Gene Name:   interleukin 10 receptor, alpha
Aliases:   CDW210A, HIL-10R, IL-10R1, IL10R
RefSeq:   NC_000011.9 NG_016275.1 NT_033899.8
Ensembl:   ENSG00000110324
Entrez:   3587
Chromosome Mapping:   11q23

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