PrimePCR™ Probe Assay: PC, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: PC, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: PC, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0024451
Assay Design:   Exonic
Chromosome Location:   11:66617092-66617212question
Amplicon Length:   91
Splice Variants Targeted:   ENST00000529047 ENST00000393955 ENST00000393958 ENST00000393960

Gene Information

This gene encodes pyruvate carboxylase which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis lipogenesis insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs but encoding the same protein have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   PC
Gene Name:   pyruvate carboxylase
Aliases:   PCB
RefSeq:   NC_000011.9 NT_167190.1 NG_008319.1
Ensembl:   ENSG00000173599
Entrez:   5091
Chromosome Mapping:   11q13.4-q13.5

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