PrimePCR™ Probe Assay: SH2B3, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: SH2B3, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: SH2B3, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0039140
Assay Design:   exonic
Chromosome Location:   12:111886086-111886211question
Amplicon Length:   96
Splice Variants Targeted:   ENST00000538307 ENST00000341259

Gene Information

This gene encodes a member of the SH2B adaptor family of proteins which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.[provided by RefSeq May 2010]

Gene Symbol:   SH2B3
Gene Name:   SH2B adaptor protein 3
Aliases:   IDDM20, LNK
RefSeq:   NC_000012.11 NG_011572.1 NG_021216.1 NT_009775.17
Ensembl:   ENSG00000111252
Entrez:   10019
Chromosome Mapping:   12q24

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