PrimePCR™ Probe Assay: APBB1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: APBB1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: APBB1, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0041663
Assay Design:   exonic
Chromosome Location:   11:6424940-6425045question
Amplicon Length:   76
Splice Variants Targeted:   ENST00000371989 ENST00000299402 ENST00000311051 ENST00000530885 ENST00000533407 ENST00000389906 ENST00000561745

Gene Information

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP) transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq Mar 2012]

Gene Symbol:   APBB1
Gene Name:   amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Aliases:   FE65, MGC:9072, RIR
RefSeq:   NC_000011.9 NG_011780.1 NT_009237.18
Ensembl:   ENSG00000166313
Entrez:   322
Chromosome Mapping:   11p15

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