PrimePCR™ Probe Assay: ARNTL2, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: ARNTL2, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: ARNTL2, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0049306
Assay Design:   exonic
Chromosome Location:   12:27553483-27553624question
Amplicon Length:   112
Splice Variants Targeted:   ENST00000544915 ENST00000395901 ENST00000546179 ENST00000311001 ENST00000261178 ENST00000266503 ENST00000457040 ENST00000542388

Gene Information

This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER ARNT SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels exposure to certain environmental pollutants and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein the structurally related MOP4 and hypoxia-inducible factors such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors this protein is coexpressed in regions of the brain such as the thalamus hypothalamus and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq Oct 2011]

Gene Symbol:   ARNTL2
Gene Name:   aryl hydrocarbon receptor nuclear translocator-like 2
Aliases:   BMAL2, CLIF, MGC149671, MGC149672, MOP9, PASD9, bHLHe6
RefSeq:   NC_000012.11 NT_009714.17
Ensembl:   ENSG00000029153
Entrez:   56938
Chromosome Mapping:   12p12.2-p11.2

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