PrimePCR™ Probe Assay: USP2, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
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PrimePCR™ PreAmp for Probe Assay: USP2, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: USP2, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0049328
Assay Design:   exonic
Chromosome Location:   11:119227608-119228008question
Amplicon Length:   107
Splice Variants Targeted:   ENST00000455332 ENST00000260187 ENST00000525735

Gene Information

This gene encodes a member of the family of de-ubiquitinating enzymes which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase murine double minute 2 (MDM2) MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq Aug 2011]

Gene Symbol:   USP2
Gene Name:   ubiquitin specific peptidase 2
Aliases:   UBP41, USP9
RefSeq:   NC_000011.9 NT_033899.8
Ensembl:   ENSG00000036672
Entrez:   9099
Chromosome Mapping:   11q23.3

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