PrimePCR™ Probe Assay: ACHE, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: ACHE, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: ACHE, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0049818
Assay Design:   exonic
Chromosome Location:   7:100490809-100490956question
Amplicon Length:   118
Splice Variants Targeted:   ENST00000419336 ENST00000241069 ENST00000428317 ENST00000412389 ENST00000426415 ENST00000430554 ENST00000411582 ENST00000302913

Gene Information

Acetylcholinesterase hydrolyzes the neurotransmitter acetylcholine at neuromuscular junctions and brain cholinergic synapses and thus terminates signal transmission. It is also found on the red blood cell membranes where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene and the structural diversity in the gene products arises from alternative mRNA splicing and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain muscle and other tissues is the hydrophilic species which forms disulfide-linked oligomers with collagenous or lipid-containing structural subunits. The other alternatively spliced form expressed primarily in the erythroid tissues differs at the C-terminal end and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq Jul 2008]

Gene Symbol:   ACHE
Gene Name:   acetylcholinesterase
Aliases:   ARACHE, N-ACHE, YT
RefSeq:   NC_000007.13 NG_007474.1 NT_007933.15
Ensembl:   ENSG00000087085
Entrez:   43
Chromosome Mapping:   7q22

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