PrimePCR™ Probe Assay: CMA1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: CMA1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: CMA1, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0049906
Assay Design:   exonic
Chromosome Location:   14:24975701-24975798question
Amplicon Length:   68
Splice Variants Targeted:   ENST00000250378 ENST00000206446

Gene Information

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix the regulation of submucosal gland secretion and the generation of vasoactive peptides. In the heart and blood vessels this protein rather than angiotensin converting enzyme is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension cardiac hypertrophy and heart failure. Thus this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq Jul 2008]

Gene Symbol:   CMA1
Gene Name:   chymase 1, mast cell
Aliases:   CYH, MCT1, MGC119890, MGC119891, chymase
RefSeq:   NC_000014.8 NT_026437.12
Ensembl:   ENSG00000092009
Entrez:   1215
Chromosome Mapping:   14q11.2

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