PrimePCR™ Probe Assay: SERPINE1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: SERPINE1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: SERPINE1, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0050406
Assay Design:   exonic
Chromosome Location:   7:100781499-100781640question
Amplicon Length:   112
Splice Variants Targeted:   ENST00000223095 ENST00000445463

Gene Information

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA) and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Sep 2009]

Gene Symbol:   SERPINE1
Gene Name:   serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Aliases:   PAI, PAI-1, PAI1, PLANH1
RefSeq:   NC_000007.13 NG_013213.1 NT_007933.15
Ensembl:   ENSG00000106366
Entrez:   5054
Chromosome Mapping:   7q21.3-q22

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