PrimePCR™ Probe Assay: CDKN1C, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: CDKN1C, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: CDKN1C, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0051546
Assay Design:   exonic
Chromosome Location:   11:2904893-2905036question
Amplicon Length:   114
Splice Variants Targeted:   ENST00000313407 ENST00000430149 ENST00000440480 ENST00000414822 ENST00000380725

Gene Information

This gene is imprinted with preferential expression of the maternal allele. The encoded protein is a tight-binding strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq Oct 2010]

Gene Symbol:   CDKN1C
Gene Name:   cyclin-dependent kinase inhibitor 1C (p57, Kip2)
Aliases:   BWCR, BWS, KIP2, WBS, p57
RefSeq:   NC_000011.9 NG_008022.1 NT_009237.18
Ensembl:   ENSG00000129757
Entrez:   1028
Chromosome Mapping:   11p15.5

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