PrimePCR™ Probe Assay: LECT1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0051929
Assay Design:   exonic
Chromosome Location:   13:53298133-53298231question
Amplicon Length:   69
Splice Variants Targeted:   ENST00000448904 ENST00000377962 ENST00000431550

Gene Information

This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq Jul 2008]

Gene Symbol:   LECT1
Gene Name:   leukocyte cell derived chemotaxin 1
Aliases:   BRICD3, CHM-I, CHM1, MYETS1
RefSeq:   NC_000013.10 NT_024524.14
Ensembl:   ENSG00000136110
Entrez:   11061
Chromosome Mapping:   13q14.3

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