PrimePCR™ Probe Assay: E2F6, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0053856
Assay Design:   exonic
Chromosome Location:   2:11593779-11593891question
Amplicon Length:   83
Splice Variants Targeted:   ENST00000381525 ENST00000307236 ENST00000542100 ENST00000546212 ENST00000362009

Gene Information

This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP) a transactivation domain enriched in acidic amino acids and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene but it has not been clearly demonstrated that they encode valid isoforms. [provided by RefSeq Jul 2008]

Gene Symbol:   E2F6
Gene Name:   E2F transcription factor 6
Aliases:   E2F-6, MGC111545
RefSeq:   NC_000002.11 NT_005334.16
Ensembl:   ENSG00000169016
Entrez:   1876
Chromosome Mapping:   2p25.1

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