PrimePCR™ Probe Assay: GSTA3, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: GSTA3, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: GSTA3, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0054293
Assay Design:   exonic
Chromosome Location:   6:52761441-52761582question
Amplicon Length:   112
Splice Variants Targeted:   ENST00000334575 ENST00000370968 ENST00000211122

Gene Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic carcinogenic and pharmacologically active electrophilic compounds. At present eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha kappa mu omega pi sigma theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However during evolution this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified but its full length sequence has not been determined. [provided by RefSeq Jul 2008]

Gene Symbol:   GSTA3
Gene Name:   glutathione S-transferase alpha 3
Aliases:   GSTA3-3, GTA3, MGC22232
RefSeq:   NC_000006.11 NT_007592.15
Ensembl:   ENSG00000174156
Entrez:   2940
Chromosome Mapping:   6p12.1

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