PrimePCR™ Probe Assay: CD59, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: CD59, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: CD59, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0058252
Assay Design:   exonic
Chromosome Location:   11:33731741-33731841question
Amplicon Length:   71
Splice Variants Targeted:   ENST00000534312 ENST00000395850 ENST00000533403 ENST00000351554 ENST00000415002 ENST00000445143 ENST00000426650 ENST00000437761 ENST00000527577 ENST00000528700

Gene Information

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex whereby it binds complement C8 and/or C9 during the assembly of this complex thereby inhibiting the incorporation of multiple copies of C9 into the complex which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency a disease resulting in hemolytic anemia and thrombosis and which causes cerebral infarction. Multiple alternatively spliced transcript variants which encode the same protein have been identified for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   CD59
Gene Name:   CD59 molecule, complement regulatory protein
Aliases:   16.3A5, 1F5, EJ16, EJ30, EL32, FLJ38134, FLJ92039, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MGC2354, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20
RefSeq:   NC_000011.9 NT_009237.18 NG_008057.1
Ensembl:   ENSG00000085063
Entrez:   966
Chromosome Mapping:   11p13

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