PrimePCR™ Probe Assay: MCM10, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0058313
Assay Design:   exonic
Chromosome Location:   10:13213057-13213182question
Amplicon Length:   96
Splice Variants Targeted:   ENST00000378714 ENST00000479669 ENST00000484800 ENST00000378694

Gene Information

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6 as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq Jul 2008]

Gene Symbol:   MCM10
Gene Name:   minichromosome maintenance complex component 10
Aliases:   CNA43, DNA43, MGC126776
RefSeq:   NC_000010.10 NT_008705.16
Ensembl:   ENSG00000065328
Entrez:   55388
Chromosome Mapping:   10p13

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