PrimePCR™ Probe Assay: TTR, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: TTR, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: TTR, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0028609
Assay Design:   Intron-spanning
Chromosome Location:   18:29171862-29172917question
Amplicon Length:   102
Splice Variants Targeted:   ENST00000237014 ENST00000432547 ENST00000541025

Gene Information

This gene encodes transthyretin one of the three prealbumins including alpha-1-antitrypsin transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition affecting predominantly peripheral nerve and/or the heart and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy euthyroid hyperthyroxinaemia amyloidotic vitreous opacities cardiomyopathy oculoleptomeningeal amyloidosis meningocerebrovascular amyloidosis carpal tunnel syndrome etc. [provided by RefSeq Jan 2009]

Gene Symbol:   TTR
Gene Name:   transthyretin
Aliases:   CTS, CTS1, HsT2651, PALB, TBPA
RefSeq:   NC_000018.9 NG_009490.1 NT_010966.14
Ensembl:   ENSG00000118271
Entrez:   7276
Chromosome Mapping:   18q12.1

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