PrimePCR™ Probe Assay: TMPRSS2, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: TMPRSS2, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: TMPRSS2, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0028919
Assay Design:   Intron-spanning
Chromosome Location:   21:42837938-42839697question
Amplicon Length:   150
Splice Variants Targeted:   ENST00000332149 ENST00000458356 ENST00000398585

Gene Information

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain a receptor class A domain a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Sep 2008]

Gene Symbol:   TMPRSS2
Gene Name:   transmembrane protease, serine 2
Aliases:   FLJ41954, PP9284, PRSS10
RefSeq:   NC_000021.8 NT_011512.11
Ensembl:   ENSG00000184012
Entrez:   7113
Chromosome Mapping:   21q22.3

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