PrimePCR™ Probe Assay: GRIK3, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: GRIK3, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: GRIK3, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0029747
Assay Design:   Intron-spanning
Chromosome Location:   1:37315916-37319255question
Amplicon Length:   120
Splice Variants Targeted:   ENST00000373091 ENST00000373093

Gene Information

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq Jul 2008]

Gene Symbol:   GRIK3
Gene Name:   glutamate receptor, ionotropic, kainate 3
Aliases:   EAA5, GLR7, GLUR7, GluR7a
RefSeq:   NC_000001.10 NG_011447.1 NT_032977.9
Ensembl:   ENSG00000163873
Entrez:   2899
Chromosome Mapping:   1p34-p33

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