PrimePCR™ Probe Assay: EDN3, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: EDN3, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: EDN3, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0030019
Assay Design:   Intron-spanning
Chromosome Location:   20:57876691-57896115question
Amplicon Length:   101
Splice Variants Targeted:   ENST00000337938 ENST00000311585 ENST00000371025 ENST00000395654 ENST00000371028

Gene Information

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS) which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq Jul 2008]

Gene Symbol:   EDN3
Gene Name:   endothelin 3
Aliases:   ET3, HSCR4, MGC15067, MGC61498, WS4B
RefSeq:   NC_000020.10 NG_008050.1 NT_011362.10
Ensembl:   ENSG00000124205
Entrez:   1908
Chromosome Mapping:   20q13.2-q13.3

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