PrimePCR™ Probe Assay: STRADA, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0030482
Assay Design:   Intron-spanning
Chromosome Location:   17:61784683-61787899question
Amplicon Length:   115
Splice Variants Targeted:   ENST00000336174 ENST00000375840 ENST00000447001 ENST00000392950 ENST00000245865

Gene Information

The protein encoded by this gene contains a STE20-like kinase domain but lacks several residues that are critical for catalytic activity so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11 also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39 also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios megalencephaly and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq Sep 2009]

Gene Symbol:   STRADA
Gene Name:   STE20-related kinase adaptor alpha
Aliases:   FLJ90524, LYK5, NY-BR-96, PMSE, STRAD, Stlk
RefSeq:   NC_000017.10 NT_010783.15 NG_015817.1
Ensembl:   ENSG00000125695
Entrez:   92335
Chromosome Mapping:   17q23.3

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