PrimePCR™ Probe Assay: HSD11B1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: HSD11B1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: HSD11B1, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0030952
Assay Design:   Intron-spanning
Chromosome Location:   1:209880360-209905815question
Amplicon Length:   119
Splice Variants Targeted:   ENST00000367028 ENST00000367027 ENST00000261465

Gene Information

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition the encoded protein can catalyze the reverse reaction the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq May 2011]

Gene Symbol:   HSD11B1
Gene Name:   hydroxysteroid (11-beta) dehydrogenase 1
Aliases:   11-DH, 11-beta-HSD1, HDL, HSD11, HSD11B, HSD11L, MGC13539, SDR26C1
RefSeq:   NC_000001.10 NT_167186.1 NG_012081.1
Ensembl:   ENSG00000117594
Entrez:   3290
Chromosome Mapping:   1q32-q41

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