PrimePCR™ Probe Assay: CNTNAP2, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: CNTNAP2, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: CNTNAP2, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0031870
Assay Design:   Intron-spanning
Chromosome Location:   7:148106523-148112585question
Amplicon Length:   88
Splice Variants Targeted:   ENST00000361727 ENST00000538075

Gene Information

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein like other neurexin proteins contains epidermal growth factor repeats and laminin G domains. In addition it includes an F5/8 type C domain discoidin/neuropilin- and fibrinogen-like domains thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2) a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders including Gilles de la Tourette syndrome schizophrenia epilepsy autism ADHD and mental retardation.[provided by RefSeq Mar 2010]

Gene Symbol:   CNTNAP2
Gene Name:   contactin associated protein-like 2
Aliases:   AUTS15, CASPR2, CDFE, DKFZp781D1846, NRXN4, PTHSL1
RefSeq:   NC_000007.13 NG_007092.2 NT_007914.15
Ensembl:   ENSG00000174469
Entrez:   26047
Chromosome Mapping:   7q35

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