PrimePCR™ Probe Assay: STIL, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: STIL, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: STIL, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0032955
Assay Design:   Intron-spanning
Chromosome Location:   1:47735465-47737801question
Amplicon Length:   98
Splice Variants Targeted:   ENST00000360380 ENST00000371877 ENST00000396221 ENST00000447475 ENST00000436811 ENST00000337817 ENST00000243182 ENST00000371874

Gene Information

This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint and disappears when cells transition to G1 phase. It interacts with a mitotic regulator and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   STIL
Gene Name:   SCL/TAL1 interrupting locus
Aliases:   DKFZp686O09161, MCPH7, SIL
RefSeq:   NC_000001.10 NG_012126.1 NT_032977.9
Ensembl:   ENSG00000123473
Entrez:   6491
Chromosome Mapping:   1q32,1p32

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