PrimePCR™ Probe Assay: ACVRL1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: ACVRL1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: ACVRL1, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0033011
Assay Design:   Intron-spanning
Chromosome Location:   12:52309234-52309896question
Amplicon Length:   98
Splice Variants Targeted:   ENST00000388922 ENST00000550683 ENST00000548659 ENST00000419526 ENST00000267008

Gene Information

This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains a glycine- and serine-rich region (called the GS domain) preceding the kinase domain and a short C-terminal tail. The encoded protein sometimes termed ALK1 shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2 also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq Jul 2008]

Gene Symbol:   ACVRL1
Gene Name:   activin A receptor type II-like 1
Aliases:   ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I
RefSeq:   NC_000012.11 NG_009549.1 NT_029419.12
Ensembl:   ENSG00000139567
Entrez:   94
Chromosome Mapping:   12q11-q14

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