PrimePCR™ Probe Assay: PDCD6IP, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: PDCD6IP, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: PDCD6IP, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0039499
Assay Design:   Intron-spanning
Chromosome Location:   3:33863536-33866787question
Amplicon Length:   118
Splice Variants Targeted:   ENST00000307296 ENST00000413073 ENST00000457054

Gene Information

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis in intralumenal endosomal vesicle formation and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition the product of this gene binds to the product of the PDCD6 gene a protein required for apoptosis in a calcium-dependent manner. This gene product also binds to endophilins proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq Jan 2012]

Gene Symbol:   PDCD6IP
Gene Name:   programmed cell death 6 interacting protein
Aliases:   AIP1, Alix, DRIP4, HP95, MGC17003
RefSeq:   NC_000003.11 NT_022517.18
Ensembl:   ENSG00000170248
Entrez:   10015
Chromosome Mapping:   3p22.3

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