PrimePCR™ Probe Assay: GAD1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: GAD1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: GAD1, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0040747
Assay Design:   Intron-spanning
Chromosome Location:   2:171675115-171686028question
Amplicon Length:   146
Splice Variants Targeted:   ENST00000454603 ENST00000358196 ENST00000344257 ENST00000455008 ENST00000456864 ENST00000375272 ENST00000525694

Gene Information

This gene encodes one of several forms of glutamic acid decarboxylase identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq Jul 2008]

Gene Symbol:   GAD1
Gene Name:   glutamate decarboxylase 1 (brain, 67kDa)
Aliases:   FLJ45882, GAD, SCP
RefSeq:   NC_000002.11 NG_021477.1 NT_005403.17
Ensembl:   ENSG00000128683
Entrez:   2571
Chromosome Mapping:   2q31

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