PrimePCR™ Probe Assay: RUNX1T1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: RUNX1T1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: RUNX1T1, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0041276
Assay Design:   Intron-spanning
Chromosome Location:   8:93026907-93029478question
Amplicon Length:   137
Splice Variants Targeted:   ENST00000523629 ENST00000396218 ENST00000360348 ENST00000422361 ENST00000520724 ENST00000518844 ENST00000521553 ENST00000518992 ENST00000521054 ENST00000519847 ENST00000517792 ENST00000522467 ENST00000517919 ENST00000521733 ENST00000520556 ENST00000521319 ENST00000520583 ENST00000523168 ENST00000436581 ENST00000265814

Gene Information

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq Nov 2010]

Gene Symbol:   RUNX1T1
Gene Name:   runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Aliases:   AML1T1, CBFA2T1, CDR, DKFZp564B213, ETO, FLJ33145, MGC2796, MTG8, ZMYND2
RefSeq:   NC_000008.10 NT_008046.16 NG_023272.1
Ensembl:   ENSG00000079102
Entrez:   862
Chromosome Mapping:   8q22

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