PrimePCR™ lncRNA® Probe Assay:ATXN2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression.

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   Same primer pair as used in SYBR assay qhsaLID0213544

List Price:    $247.00
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PrimePCR™ IncRNA PreAmp for Probe Assay: ATXN2, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ IncRNA Template for Probe Assay: ATXN2, Human
Reaction:     4 billion copies/200 µl
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   lncRNA Expression
Unique Assay ID:   qhsaLIP0214980
Assay Design:   intron_spanning
Chromosome Location:   chr12:111520015-111520931question
Amplicon Length:   82
Splice Variants Targeted:   ENST00000542287 ENST00000392645 ENST00000548492 ENST00000550236 ENST00000471866 ENST00000389153 ENST00000549455 ENST00000483311 ENST00000608853 ENST00000535949 ENST00000616825 ENST00000377617 ENST00000550104
LNCipedia Splice Variants Targeted:   lnc-BRAP-1:1

Gene Information

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum brain stem and spinal cord. Clinically ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy ophthalmoplegia bulbar and extrapyramidal signs peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. This locus has been mapped to chromosome 12 and it has been determined that the diseased allele contains 37-50 CAG repeats compared to 17-29 in the normal allele. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined. [provided by RefSeq Jan 2010]

Gene Symbol:   ATXN2
Gene Name:   ataxin 2
Aliases:   ATX2, FLJ46772, SCA2, TNRC13
RefSeq:   NG_021216.1 NC_000012.11 NG_011572.1 NT_009775.17
Ensembl:   ENSG00000204842
LNCipedia:   lnc-BRAP-1
Entrez:   6311
Chromosome Mapping:   12q24.1
Gene Strand:   Not Available

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