PrimePCR™ Probe Assay: Dio2, Mouse

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qMmuCEP0052679
Assay Design:   exonic
Chromosome Location:   12:90726289-90726434question
Amplicon Length:   116
Splice Variants Targeted:   ENSMUST00000082432

Gene Information

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 33'5-triiodothyronine (T3). Knockout studies in mice suggest that this gene may play a role in brown adipose tissue lipogenesis auditory function and bone formation. This protein contains selenocysteine (Sec) residues encoded by the UGA codon which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure the sec insertion sequence (SECIS) which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq Jul 2008]

Gene Symbol:   Dio2
Gene Name:   Deiodinase, iodothyronine, type II
Aliases:   5DII, AI324267, DIOII
RefSeq:   NC_000078.6 NT_039551.8
Ensembl:   ENSMUSG00000007682
Entrez:   13371
Chromosome Mapping:   12 D3|12

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