PrimePCR™ Probe Assay: Trem2, Mouse

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: Trem2, Mouse
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: Trem2, Mouse
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qMmuCEP0054571
Assay Design:   exonic
Chromosome Location:   17:48352080-48352211question
Amplicon Length:   102
Splice Variants Targeted:   ENSMUST00000024791 ENSMUST00000113237

Gene Information

The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors such as kinases and phospholipase C-gamma to form a receptor signaling complex that activates myeloid cells including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq Jan 2013]

Gene Symbol:   Trem2
Gene Name:   Triggering receptor expressed on myeloid cells 2
Aliases:   Trem2a, Trem2b, Trem2c
RefSeq:   NC_000083.6 NT_039649.8
Ensembl:   ENSMUSG00000023992
Entrez:   83433
Chromosome Mapping:   17 C|17

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