Gene:  DLAT, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene dihydrolipoamide acetyltransferase accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq Oct 2009]

PrimePCR™ SYBR® Green Assay: DLAT, Human
dihydrolipoamide S-acetyltransferase

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0045488
Info:   Same primer pair as used in probe assay qHsaCEP0052749
List Price:    $146.00
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PrimePCR™ SYBR® Green Assay: DLAT, Human
dihydrolipoamide S-acetyltransferase

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0012546
Info:   Recommended - best efficiency
List Price:    $146.00
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PrimePCR™ lncRNA SYBR® Green Assay:DLAT, Human
dihydrolipoamide S-acetyltransferase

Assay Type: SYBR® Green
Assay Design: exonic
Application: lncRNA Expression
Unique Assay ID: qhsaLED0104226
Info:   Same primer pair as used in probe assay qhsaLEP0181466
List Price:    $142.00
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PrimePCR™ Probe Assay: DLAT, Human
dihydrolipoamide S-acetyltransferase

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0052749
List Price:    $214.00
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PrimePCR™ lncRNA® Probe Assay:DLAT, Human
dihydrolipoamide S-acetyltransferase

Assay Type: Probe
Assay Design: exonic
Application: lncRNA Expression
Unique Assay ID: qhsaLEP0181466
Info:   Same primer pair as used in SYBR assay qhsaLED0104226
List Price:    $208.00
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