Gene:  E2F4, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP) a transactivation domain enriched in acidic amino acids and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB p107 and p130 but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: E2F4, Human
E2F transcription factor 4, p107/p130-binding

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0048496
Info:   Recommended - best coverage; Same primer pair as used in probe assay qHsaCEP0055756
List Price:    $153.00
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PrimePCR™ SYBR® Green Assay: E2F4, Human
E2F transcription factor 4, p107/p130-binding

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0012808
List Price:    $153.00
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PrimePCR™ Probe Assay: E2F4, Human
E2F transcription factor 4, p107/p130-binding

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0055756
List Price:    $225.00
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