Gene:  HLA-C, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide exons 2 and 3 encode the alpha1 and alpha2 domain which both bind the peptide exon 4 encodes the alpha3 domain exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: HLA-C, Human
major histocompatibility complex, class I, C

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0037340
Info:   Same primer pair as used in probe assay qHsaCEP0040063
List Price:    $153.00
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PrimePCR™ Probe Assay: HLA-C, Human
major histocompatibility complex, class I, C

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0040063
List Price:    $225.00
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