Gene:  MC1R, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein a seven pass transmembrane G protein coupled receptor controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq Jul 2008]

PrimePCR™ SYBR® Green Assay: MC1R, Human
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0037866
Info:   Same primer pair as used in probe assay qHsaCEP0040589
List Price:    $146.00
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PrimePCR™ Probe Assay: MC1R, Human
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0040589
List Price:    $214.00
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