Gene:  PSEN1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase an enzyme that cleaves APP. Also it is thought that the presenilins are involved in the cleavage of the Notch receptor such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene the full-length nature of only some have been determined. [provided by RefSeq Aug 2008]

PrimePCR™ SYBR® Green Assay: PSEN1, Human
presenilin 1

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0005570
Info:   Recommended - best coverage
List Price:    $153.00
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PrimePCR™ SYBR® Green Assay: PSEN1, Human
presenilin 1

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0057330
Info:   Same primer pair as used in probe assay qHsaCEP0058435
List Price:    $153.00
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PrimePCR™ Probe Assay: PSEN1, Human
presenilin 1

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0058435
List Price:    $225.00
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