Gene:  ROBO3, Human

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This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth growth cone guidance and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3 a family of secreted chemorepellants are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis leukocyte migration kidney morphogenesis angiogenesis and vasculogenesis in addition to neurogenesis. This gene ROBO3 has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs a transmembrane segment and a cytoplasmic tail with three conserved signaling motifs: CC0 CC2 and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze progressive scoliosis and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated. [provided by RefSeq Dec 2009]

PrimePCR™ SYBR® Green Assay: ROBO3, Human
roundabout, axon guidance receptor, homolog 3 (Drosophila)

Assay Type: SYBR® Green
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCID0022446
Info:   Same primer pair as used in probe assay qHsaCIP0033431
List Price:    $153.00
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PrimePCR™ Probe Assay: ROBO3, Human
roundabout, axon guidance receptor, homolog 3 (Drosophila)

Assay Type: Probe
Assay Design: Intron-spanning
Application: Gene Expression
Unique Assay ID: qHsaCIP0033431
List Price:    $225.00
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