Gene:  TNNT3, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair gene expression assay target

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The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which ultimately produces a muscle contraction. The troponin complex has protein subunits C I and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal- slow skeletal- and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq Oct 2009]

PrimePCR™ SYBR® Green Assay: TNNT3, Human
troponin T type 3 (skeletal, fast)

Assay Type: SYBR® Green
Assay Design: Exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0005032
Info:   Recommended - best coverage
List Price:    $146.00
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PrimePCR™ SYBR® Green Assay: TNNT3, Human
troponin T type 3 (skeletal, fast)

Assay Type: SYBR® Green
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCED0044325
Info:   Same primer pair as used in probe assay qHsaCEP0051587
List Price:    $146.00
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PrimePCR™ Probe Assay: TNNT3, Human
troponin T type 3 (skeletal, fast)

Assay Type: Probe
Assay Design: exonic
Application: Gene Expression
Unique Assay ID: qHsaCEP0051587
List Price:    $214.00
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