Cell adhesion - Cadherin-mediated cell adhesion

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Human PrimePCR Selections

Cadherin Mediated Cell Adhesion H96

Predesigned 96-well panel for use with SYBR® Green

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Cadherin Mediated Cell Adhesion H384

Predesigned 384-well panel for use with SYBR® Green

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Cadherin-mediated cell adhesion

Cadherins are calcium-dependent homophilic cell adhesion proteins essential for tissue organization. Establishment of stable cell-cell adhesion depends on association of classical Cadherins with Catenins, which links cell surface adhesion and recognition to both Actin cytoskeleton and cell signaling pathways. Catenin (cadherin-associated protein), beta 1 (Beta-catenin) binds with high affinity to the distal Cadherin cytoplasmic tail and, in turn, recruits Catenin (cadherin-associated protein), alpha 1, 102kDa (Alpha-catenin) to the complex. Alpha-catenin binds to Actin filaments directly and can also associate with a range of other actin-binding proteins such as Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4 (AF-6) and Formin. In contrast, Catenin delta 1 (p120-catenin) binds directly to Cadherin independently of the other catenins. Cadherin-Catenins complex can further interact with a range of signaling molecules which participate in either cellular signaling or control of cytoskeletal dynamics [1]. Stability of the Cadherin/ Catenins complex and thereby the integrity of adherent junction is controlled by phosphorylation/ dephosphorylation. Phosphorylation of Beta-catenin by receptor- and non-receptor-types tyrosine kinases results in dissociation of Alpha-catenin from Beta-catenin with concomitant loss of cadherin adhesion, whereas tyrosine phosphatases ensure or restore the integrity of Cadherin-mediated adhesions [2].

References:

Goodwin M, Yap AS
Classical cadherin adhesion molecules: coordinating cell adhesion, signaling and the cytoskeleton. Journal of molecular histology 2004 Nov;35(8-9):839-44
Lilien J, Balsamo J
The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin. Current opinion in cell biology 2005 Oct;17(5):459-65

Target Details

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Terms and Conditions

GeneCode	Cadherin Mediated Cell Adhesion H96	Cadherin Mediated Cell Adhesion H384
ACTA1	✓	✓
ACTA2	✓	✓
ACTB	✓	✓
ACTC1	✓	✓
ACTG1	✓	✓
CDC42	✓	✓
CDH1	✓	✓
CDH2	✓	✓
CDH3	✓	✓
CDH5	✓	✓
CTNNA1	✓	✓
CTNNB1	✓	✓
CTNND1	✓	✓
CTTN	✓	✓
FYN	✓	✓
GAPDH	✓	✓
HPRT1	✓	✓
JUP	✓	✓
MET	✓	✓
MLLT4	✓	✓
PTK2	✓	✓
PTPN11	✓	✓
PTPRF	✓	✓
PTPRJ	✓	✓
PTPRM	✓	✓
SRC	✓	✓
TBP	✓	✓

GeneCode	Cadherin Mediated Cell Adhesion M96	Cadherin Mediated Cell Adhesion M384
Acta1	✓	✓
Acta2	✓	✓
Actb	✓	✓
Actc1	✓	✓
Actg1	✓	✓
Cdc42	✓	✓
Cdh1	✓	✓
Cdh2	✓	✓
Cdh3	✓	✓
Cdh5	✓	✓
Ctnna1	✓	✓
Ctnnb1	✓	✓
Ctnnd1	✓	✓
Cttn	✓	✓
Fyn	✓	✓
Gapdh	✓	✓
Hprt	✓	✓
Jup	✓	✓
Met	✓	✓
Mllt4	✓	✓
Ptk2	✓	✓
Ptpn11	✓	✓
Ptprf	✓	✓
Ptprj	✓	✓
Ptprm	✓	✓
Src	✓	✓
Tbp	✓	✓

GeneCode	Cadherin-mediated cell adhesion R96	Cadherin-mediated cell adhesion R384
Acta1	✓	✓
Actb	✓	✓
Actc1	✓	✓
Actg1	✓	✓
Arpc1b	✓	✓
Cdc42	✓	✓
Cdh1	✓	✓
Cdh2	✓	✓
Cdh3	✓	✓
Cdh5	✓	✓
Ctnna1	✓	✓
Ctnnb1	✓	✓
Ctnnd1	✓	✓
Cttn	✓	✓
Fyn	✓	✓
Gapdh	✓	✓
Hprt1	✓	✓
Jup	✓	✓
Met	✓	✓
Mllt4	✓	✓
Ptk2	✓	✓
Ptpn11	✓	✓
Ptprf	✓	✓
Ptprj	✓	✓
Ptprm	✓	✓
Src	✓	✓
Tbp	✓	✓

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