PrimePCR™ Probe Assay: FGFR3, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0049530
Assay Design:   exonic
Chromosome Location:   4:1810283-1810392question
Amplicon Length:   80
Splice Variants Targeted:   ENST00000481110 ENST00000260795 ENST00000352904 ENST00000340107 ENST00000440486 ENST00000412135

Gene Information

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region composed of three immunoglobulin-like domains a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors setting in motion a cascade of downstream signals ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq Jul 2009]

Gene Symbol:   FGFR3
Gene Name:   fibroblast growth factor receptor 3
Aliases:   ACH, CD333, CEK2, HSFGFR3EX, JTK4
RefSeq:   NC_000004.11 NG_012632.1 NT_006051.18
Ensembl:   ENSG00000068078
Entrez:   2261
Chromosome Mapping:   4p16.3

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