PrimePCR™ Probe Assay: XIAP, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0040632
Assay Design:   exonic
Chromosome Location:   X:123019683-123019906question
Amplicon Length:   194
Splice Variants Targeted:   ENST00000430625 ENST00000371199 ENST00000355640 ENST00000434753

Gene Information

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed baculovirus IAP repeat which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione a potent inducer of free radicals and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq Feb 2011]

Gene Symbol:   XIAP
Gene Name:   X-linked inhibitor of apoptosis
Aliases:   API3, BIRC4, FLJ26913, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3
RefSeq:   NC_000023.10 NG_007264.1 NT_011786.16
Ensembl:   ENSG00000101966
Entrez:   331
Chromosome Mapping:   Xq25

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