PrimePCR™ Probe Assay: LMNA, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0053172
Assay Design:   exonic
Chromosome Location:   1:156106715-156106907question
Amplicon Length:   79
Splice Variants Targeted:   ENST00000392353 ENST00000361308 ENST00000347559 ENST00000508500 ENST00000473598 ENST00000368297 ENST00000448611 ENST00000368299 ENST00000368300 ENST00000368301

Gene Information

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability chromatin structure and gene expression. Vertebrate lamins consist of two types A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy familial partial lipodystrophy limb girdle muscular dystrophy dilated cardiomyopathy Charcot-Marie-Tooth disease and Hutchinson-Gilford progeria syndrome. [provided by RefSeq Apr 2012]

Gene Symbol:   LMNA
Gene Name:   lamin A/C
Aliases:   CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
RefSeq:   NC_000001.10 NG_008692.1 NT_004487.19
Ensembl:   ENSG00000160789
Entrez:   4000
Chromosome Mapping:   1q22

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