PrimePCR™ Probe Assay: VDR, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: VDR, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: VDR, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0033714
Assay Design:   Intron-spanning
Chromosome Location:   12:48251436-48272761question
Amplicon Length:   147
Splice Variants Targeted:   ENST00000395324 ENST00000549336 ENST00000550325 ENST00000546653 ENST00000550314 ENST00000548664 ENST00000229022 ENST00000535672

Gene Information

This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq Feb 2011]

Gene Symbol:   VDR
Gene Name:   vitamin D (1,25- dihydroxyvitamin D3) receptor
Aliases:   NR1I1
RefSeq:   NC_000012.11 NT_029419.12 NG_008731.1
Ensembl:   ENSG00000111424
Entrez:   7421
Chromosome Mapping:   12q13.11

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